What is inside of a neuron A neuron has many of the same. Nevertheless, a clear logic underlying the transcriptional control of neuronal connectivity has yet to emerge. Single-cell RNA sequencing has revealed a vast transcriptional diversity of neurons. Read more about how to correctly acknowledge RSC content. Neurons have specialize cell parts called dendrites and axons. Modular transcriptional programs separately define axon and dendrite connectivity Patterns of synaptic connectivity are remarkably precise and complex. Permission is not required) please go to the Copyright If you want to reproduce the wholeĪrticle in a third-party commercial publication (excluding your thesis/dissertation for which If you are the author of this article, you do not need to request permission to reproduce figuresĪnd diagrams provided correct acknowledgement is given. Provided correct acknowledgement is given. If you are an author contributing to an RSC publication, you do not need to request permission Please go to the Copyright Clearance Center request page. To request permission to reproduce material from this article in a commercial publication, Provided that the correct acknowledgement is given and it is not used for commercial purposes. The examples below assume that you have started a REPL in a project that imports dendrite as dendrite '0.5.14' and required the re namespace as (require re:as d) Read and write files. This article in other publications, without requesting further permission from the RSC, Properties of immature and mature dendritic cells: phenotype, morphology, phagocytosis, and migrationĬreative Commons Attribution-NonCommercial 3.0 Unported Licence. These findings could be helpful for understanding the relationship between immature and mature DCs and analyzing initiation of the adaptive immune response by DCs in DC-mediated immunotherapy. The phagocytic and migratory ability studied using the polymer bead uptake test and live imaging indicated that immature DCs have a pronounced phagocytic ability compared to mature DCs, while the mature DCs moves faster than immature DCs. Immature DCs were of a circular shape and expressed low levels of costimulatory molecules, while mature DCs had longer dendrites and expressed high levels of costimulatory molecules. In this paper, the morphological and phenotypical status of DCs in both stages were compared, and their relationship to the phagocytic and migratory ability of the cells was studied using bone-marrow derived dendritic cells (BMDCs). Understanding these properties of DCs is important in the context of recent efforts on the developments of biomaterials-based cancer vaccine. The change of phenotype is closely associated with the morphological and functional characteristics of DCs. To mediate innate and adaptive immunity, DCs pass through two stages: immature and mature. Dendritic cells (DCs) are antigen-presenting cells that play an important role in connecting the innate and adaptive immunity of the immune system.
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